Serum brain-derived neurotrophic factor (BDNF) concentrations in pregnant women with post-traumatic stress disorder and comorbid depression

2.50
Hdl Handle:
http://hdl.handle.net/10757/610659
Title:
Serum brain-derived neurotrophic factor (BDNF) concentrations in pregnant women with post-traumatic stress disorder and comorbid depression
Authors:
Yang, Na; Gelaye, Bizu; Zhong, Qiuyue; Rondon, Marta B.; Sanchez, Sixto E.; Williams, Michelle A.
Citation:
Serum brain-derived neurotrophic factor (BDNF) concentrations in pregnant women with post-traumatic stress disorder and comorbid depression 2016 Archives of Women's Mental Health
Publisher:
Springer International Publishing
Journal:
Archives of Women's Mental Health (Arch Womens Ment Health)
Issue Date:
19-May-2016
URI:
http://hdl.handle.net/10757/610659
DOI:
10.1007/s00737-016-0638-0
Additional Links:
http://link.springer.com/10.1007/s00737-016-0638-0
Abstract:
There is accumulating evidence for the role of brain-derived neurotrophic factor (BDNF) in the pathophysiology of depression. However, the role of BDNF in the pathophysiology of post-traumatic stress disorder (PTSD) remains controversial, and no study has assessed BDNF concentrations among pregnant women with PTSD. We examined early-pregnancy BDNF concentrations among women with PTSD with and without depression. A total of 2928 women attending prenatal care clinics in Lima, Peru, were recruited. Antepartum PTSD and depression were evaluated using PTSD Checklist—Civilian Version (PCL-C) and Patient Health Questionnaire-9 (PHQ-9) scales, respectively. BDNF concentrations were measured in a subset of the cohort (N = 944) using a competitive enzyme-linked immunosorbent assay (ELISA). Logistic regression procedures were used to estimate odds ratios (OR) and 95 % confidence intervals (95 % CI). Antepartum PTSD (37.4 %) and depression (27.6 %) were prevalent in this cohort of low-income pregnant Peruvian women. Approximately 19.9 % of participants had comorbid PTSD-depression. Median serum BDNF concentrations were lower among women with comorbid PTSD-depression as compared with women without either condition (median [interquartile range], 20.44 [16.97–24.30] vs. 21.35 [17.33–26.01] ng/ml; P = 0.06). Compared to the referent group (those without PTSD and depression), women with comorbid PTSD-depression were 1.52-fold more likely to have low (<25.38 ng/ml) BDNF concentrations (OR = 1.52; 95 % CI 1.00–2.31). We observed no evidence of reduced BDNF concentrations among women with isolated PTSD. BDNF concentrations in early pregnancy were only minimally and non-significantly reduced among women with antepartum PTSD. Reductions in BDNF concentrations were more pronounced among women with comorbid PTSD-depression.
Type:
info:eu-repo/semantics/article
Rights:
info:eu-repo/semantics/embargoedAccess
Language:
eng
Description:
El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.
Keywords:
Biomarker; BDNF; Antepartum PTSD; Antepartum depression; Peru
ISSN:
1434-1816; 1435-1102
Email:
bgelaye@hsph.harvard.edu

Full metadata record

DC FieldValue Language
dc.contributor.authorYang, Naes_PE
dc.contributor.authorGelaye, Bizues_PE
dc.contributor.authorZhong, Qiuyuees_PE
dc.contributor.authorRondon, Marta B.es_PE
dc.contributor.authorSanchez, Sixto E.es_PE
dc.contributor.authorWilliams, Michelle A.es_PE
dc.date.accessioned2016-05-24T17:45:52Zes_PE
dc.date.available2016-05-24T17:45:52Zes_PE
dc.date.issued2016-05-19es_PE
dc.identifier.citationSerum brain-derived neurotrophic factor (BDNF) concentrations in pregnant women with post-traumatic stress disorder and comorbid depression 2016 Archives of Women's Mental Healthes_PE
dc.identifier.issn1434-1816es_PE
dc.identifier.issn1435-1102es_PE
dc.identifier.doi10.1007/s00737-016-0638-0es_PE
dc.identifier.urihttp://hdl.handle.net/10757/610659es_PE
dc.descriptionEl texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.es_PE
dc.description.abstractThere is accumulating evidence for the role of brain-derived neurotrophic factor (BDNF) in the pathophysiology of depression. However, the role of BDNF in the pathophysiology of post-traumatic stress disorder (PTSD) remains controversial, and no study has assessed BDNF concentrations among pregnant women with PTSD. We examined early-pregnancy BDNF concentrations among women with PTSD with and without depression. A total of 2928 women attending prenatal care clinics in Lima, Peru, were recruited. Antepartum PTSD and depression were evaluated using PTSD Checklist—Civilian Version (PCL-C) and Patient Health Questionnaire-9 (PHQ-9) scales, respectively. BDNF concentrations were measured in a subset of the cohort (N = 944) using a competitive enzyme-linked immunosorbent assay (ELISA). Logistic regression procedures were used to estimate odds ratios (OR) and 95 % confidence intervals (95 % CI). Antepartum PTSD (37.4 %) and depression (27.6 %) were prevalent in this cohort of low-income pregnant Peruvian women. Approximately 19.9 % of participants had comorbid PTSD-depression. Median serum BDNF concentrations were lower among women with comorbid PTSD-depression as compared with women without either condition (median [interquartile range], 20.44 [16.97–24.30] vs. 21.35 [17.33–26.01] ng/ml; P = 0.06). Compared to the referent group (those without PTSD and depression), women with comorbid PTSD-depression were 1.52-fold more likely to have low (<25.38 ng/ml) BDNF concentrations (OR = 1.52; 95 % CI 1.00–2.31). We observed no evidence of reduced BDNF concentrations among women with isolated PTSD. BDNF concentrations in early pregnancy were only minimally and non-significantly reduced among women with antepartum PTSD. Reductions in BDNF concentrations were more pronounced among women with comorbid PTSD-depression.es_PE
dc.formatapplication/htmles_PE
dc.language.isoenges_PE
dc.publisherSpringer International Publishinges_PE
dc.relation.urlhttp://link.springer.com/10.1007/s00737-016-0638-0es_PE
dc.rightsinfo:eu-repo/semantics/embargoedAccesses_PE
dc.sourceUniversidad Peruana de Ciencias Aplicadas (UPC)es_PE
dc.sourceRepositorio Académico - UPCes_PE
dc.subjectBiomarkeres_PE
dc.subjectBDNFes_PE
dc.subjectAntepartum PTSDes_PE
dc.subjectAntepartum depressiones_PE
dc.subjectPerues_PE
dc.titleSerum brain-derived neurotrophic factor (BDNF) concentrations in pregnant women with post-traumatic stress disorder and comorbid depressiones_PE
dc.typeinfo:eu-repo/semantics/articlees_PE
dc.identifier.journalArchives of Women's Mental Health (Arch Womens Ment Health)es_PE
dc.description.peer-reviewRevisión por pareses_PE
dc.contributor.emailbgelaye@hsph.harvard.edues_PE
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