Prevalence of BRCA1 and BRCA2 mutations in unselected breast cancer patients from Peru.

2.50
Hdl Handle:
http://hdl.handle.net/10757/610590
Title:
Prevalence of BRCA1 and BRCA2 mutations in unselected breast cancer patients from Peru.
Authors:
Abugattas, J; Llacuachaqui, M; Allende, Y Sullcahuaman; Velásquez, A Arias; Velarde, R; Cotrina, J; Garcés, M; León, M; Calderón, G; de la Cruz, M; Mora, P; Royer, R; Herzog, J; Weitzel, J N; Narod, S A
Citation:
Prevalence of BRCA1 and BRCA2 mutations in unselected breast cancer patients from Peru. 2015, 88 (4):371-5 Clin. Genet.
Publisher:
John Wiley & Sons, Inc.
Journal:
Clinical genetics (Clin Genet.)
Issue Date:
Oct-2015
URI:
http://hdl.handle.net/10757/610590
DOI:
10.1111/cge.12505
PubMed ID:
25256238
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/25256238
Abstract:
The prevalence of BRCA1 and BRCA2 mutations among breast cancer patients in Peru has not yet been explored. We enrolled 266 women with breast cancer from a National cancer hospital in Lima, Peru, unselected for age or family history. DNA was screened with a panel of 114 recurrent Hispanic BRCA mutations (HISPANEL). Among the 266 cases, 13 deleterious mutations were identified (11 in BRCA1 and 2 in BRCA2), representing 5% of the total. The average age of breast cancer in the mutation-positive cases was 44 years. BRCA1 185delAG represented 7 of 11 mutations in BRCA1. Other mutations detected in BRCA1 included: two 2080delA, one 943ins10, and one 3878delTA. The BRCA2 3036del4 mutation was seen in two patients. Given the relatively low cost of the HISPANEL test, one should consider offering this test to all Peruvian women with breast or ovarian cancer.
Type:
info:eu-repo/semantics/article
Rights:
info:eu-repo/semantics/embargoedAccess
Language:
eng
Description:
El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.
Keywords:
BRCA1; BRCA2; Peru; Breast cancer; Hereditary
ISSN:
1399-0004
Email:
steven.narod@wchospital.ca

Full metadata record

DC FieldValue Language
dc.contributor.authorAbugattas, Jes_PE
dc.contributor.authorLlacuachaqui, Mes_PE
dc.contributor.authorAllende, Y Sullcahuamanes_PE
dc.contributor.authorVelásquez, A Ariases_PE
dc.contributor.authorVelarde, Res_PE
dc.contributor.authorCotrina, Jes_PE
dc.contributor.authorGarcés, Mes_PE
dc.contributor.authorLeón, Mes_PE
dc.contributor.authorCalderón, Ges_PE
dc.contributor.authorde la Cruz, Mes_PE
dc.contributor.authorMora, Pes_PE
dc.contributor.authorRoyer, Res_PE
dc.contributor.authorHerzog, Jes_PE
dc.contributor.authorWeitzel, J Nes_PE
dc.contributor.authorNarod, S Aes_PE
dc.date.accessioned2016-05-23T16:20:52Zes_PE
dc.date.available2016-05-23T16:20:52Zes_PE
dc.date.issued2015-10es_PE
dc.identifier.citationPrevalence of BRCA1 and BRCA2 mutations in unselected breast cancer patients from Peru. 2015, 88 (4):371-5 Clin. Genet.es_PE
dc.identifier.issn1399-0004es_PE
dc.identifier.pmid25256238es_PE
dc.identifier.doi10.1111/cge.12505es_PE
dc.identifier.urihttp://hdl.handle.net/10757/610590es_PE
dc.descriptionEl texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.es_PE
dc.description.abstractThe prevalence of BRCA1 and BRCA2 mutations among breast cancer patients in Peru has not yet been explored. We enrolled 266 women with breast cancer from a National cancer hospital in Lima, Peru, unselected for age or family history. DNA was screened with a panel of 114 recurrent Hispanic BRCA mutations (HISPANEL). Among the 266 cases, 13 deleterious mutations were identified (11 in BRCA1 and 2 in BRCA2), representing 5% of the total. The average age of breast cancer in the mutation-positive cases was 44 years. BRCA1 185delAG represented 7 of 11 mutations in BRCA1. Other mutations detected in BRCA1 included: two 2080delA, one 943ins10, and one 3878delTA. The BRCA2 3036del4 mutation was seen in two patients. Given the relatively low cost of the HISPANEL test, one should consider offering this test to all Peruvian women with breast or ovarian cancer.es_PE
dc.language.isoenges_PE
dc.publisherJohn Wiley & Sons, Inc.es_PE
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/25256238es_PE
dc.rightsinfo:eu-repo/semantics/embargoedAccesses_PE
dc.sourceUniversidad Peruana de Ciencias Aplicadas (UPC)es_PE
dc.sourceRepositorio Académico - UPCes_PE
dc.subjectBRCA1es_PE
dc.subjectBRCA2es_PE
dc.subjectPerues_PE
dc.subjectBreast canceres_PE
dc.subjectHereditaryes_PE
dc.titlePrevalence of BRCA1 and BRCA2 mutations in unselected breast cancer patients from Peru.es_PE
dc.typeinfo:eu-repo/semantics/articlees_PE
dc.identifier.journalClinical genetics (Clin Genet.)es_PE
dc.description.peer-reviewRevisión por pareses_PE
dc.contributor.emailsteven.narod@wchospital.caes_PE
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