Comparative analysis of antimicrobial resistance in enterotoxigenic Escherichia coli isolates from two paediatric cohort studies in Lima, Peru
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Authors
Medina, Anicia M.Rivera, Fulton P.
Pons, Maria J
Riveros, Maribel
Gomes, Cláudia
Bernal, María
Meza, Rina
Maves, Ryan C.
Huicho, Luis
Chea Woo, Elsa
Lanata, Claudio F.
Gil, Ana I.
Ochoa, Theresa J.
Ruiz, Joaquim
Issue Date
2015-08xmlui.metadata.dc.contributor.email
[email protected]
Metadata
Show full item recordCitation
Comparative analysis of antimicrobial resistance in enterotoxigenic Escherichia coli isolates from two paediatric cohort studies in Lima, Peru 2015, 109 (8):493 Transactions of The Royal Society of Tropical Medicine and HygienePublisher
Oxford University PressJournal
Transactions of The Royal Society of Tropical Medicine and Hygiene (Trans R Soc Trop Med Hyg.)DOI
10.1093/trstmh/trv054Additional Links
http://trstmh.oxfordjournals.org/lookup/doi/10.1093/trstmh/trv054Abstract
Background Antibiotic resistance is increasing worldwide, being of special concern in low- and middle-income countries. The aim of this study was to determine the antimicrobial susceptibility and mechanisms of resistance in 205 enterotoxigenic Escherichia coli (ETEC) isolates from two cohort studies in children <24 months in Lima, Peru. Methods ETEC were identified by an in-house multiplex real-time PCR. Susceptibility to 13 antimicrobial agents was tested by disk diffusion; mechanisms of resistance were evaluated by PCR. Results ETEC isolates were resistant to ampicillin (64%), cotrimoxazole (52%), tetracycline (37%); 39% of the isolates were multidrug-resistant. Heat-stable toxin producing (ETEC-st) (48%) and heat-labile toxin producing ETEC (ETEC-lt) (40%) had higher rates of multidrug resistance than isolates producing both toxins (ETEC-lt-st) (21%), p<0.05. Only 10% of isolates were resistant to nalidixic acid and none to ciprofloxacin or cefotaxime. Ampicillin and sulfamethoxazole resistance were most often associated with blaTEM (69%) and sul2 genes (68%), respectively. Tetracycline resistance was associated with tet(A) (49%) and tet(B) (39%) genes. Azithromycin inhibitory diameters were ≤15 mm in 36% of isolates, with 5% of those presenting the mph(A) gene. Conclusions ETEC from Peruvian children are often resistant to older, inexpensive antibiotics, while remaining susceptible to ciprofloxacin, cephalosporins and furazolidone. Fluoroquinolones and azithromycin remain the drugs of choice for ETEC infections in Peru. However, further development of resistance should be closely monitored.Type
info:eu-repo/semantics/articleRights
info:eu-repo/semantics/embargoedAccessLanguage
engDescription
El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.ISSN
0035-92031878-3503
ae974a485f413a2113503eed53cd6c53
10.1093/trstmh/trv054
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