Placental genetic variations in circadian clock-related genes increase the risk of placental abruption

2.50
Hdl Handle:
http://hdl.handle.net/10757/607302
Title:
Placental genetic variations in circadian clock-related genes increase the risk of placental abruption
Authors:
Chunfang, Qiu; Gelaye, Bizu; Denis, Marie; Tadesse, Mahlet G.; Enquobahrie, Daniel A.; Ananth, Cande V.; Pacora, Percy N.; Salazar, Manuel; Sanchez, Sixto E.; Williams, Michelle A.
Publisher:
International Journal of Molecular Epidemiology and Genetics
Journal:
International Journal of Molecular Epidemiology and Genetics (Int J Mol Epidemiol Genet)
Issue Date:
Mar-2016
URI:
http://hdl.handle.net/10757/607302
Additional Links:
http://www.ijmeg.org/IJMEG_V7N1.html
Abstract:
The genetic architecture of placental abruption (PA) remains poorly understood. We examined variations in SNPs of circadian clock-related genes in placenta with PA risk. We also explored placental and maternal genomic contributions to PA risk. Placental genomic DNA samples were isolated from 280 PA cases and 244 controls. Genotyping was performed using the Illumina Cardio-MetaboChip. We examined 116 SNPs in 13 genes known to moderate circadian rhythms. Logistic regression models were fit to estimate odds ratios (ORs). The combined effect of multiple SNPs on PA risk was estimated using a weighted genetic risk score. We examined independent and joint associations of wGRS derived from placental and maternal genomes with PA. Seven SNPs in five genes (ARNTL2, CRY2, DEC1, PER3 and RORA), in the placental genome, were associated with PA risk. Each copy of the minor allele (G) of a SNP in the RORA gene (rs2899663) was associated with a 30% reduced odds of PA (95% CI 0.52-0.95). The odds of PA increased with increasing placental-wGRS (P<sub>trend</sub><0.001). The ORs were 1.00, 2.16, 3.24 and 4.48 across quartiles. Associations persisted after the maternal-wGRS was included in the model. There was evidence of an additive contribution of placental and maternal genetic contributions to PA risk. Participants with placental- and maternal-wGRS in the highest quartile, compared with those in the lowest quartile, had a 15.57-fold (95% CI 3.34- 72.60) increased odds of PA. Placental variants in circadian clock-related genes are associated with PA risk; and the association persists after control of genetic variants in the maternal genome
Type:
info:eu-repo/semantics/article
Rights:
info:eu-repo/semantics/openAccess
Language:
eng
Keywords:
Circadian gene; Placental abruption; Pregnancy; Pregnancy; Placentae; SNPs
ISSN:
1948-1756
Email:
Chun-fang.Qiu@Swedish.org

Full metadata record

DC FieldValue Language
dc.contributor.authorChunfang, Qiues_PE
dc.contributor.authorGelaye, Bizues_PE
dc.contributor.authorDenis, Mariees_PE
dc.contributor.authorTadesse, Mahlet G.es_PE
dc.contributor.authorEnquobahrie, Daniel A.es_PE
dc.contributor.authorAnanth, Cande V.es_PE
dc.contributor.authorPacora, Percy N.es_PE
dc.contributor.authorSalazar, Manueles_PE
dc.contributor.authorSanchez, Sixto E.es_PE
dc.contributor.authorWilliams, Michelle A.es_PE
dc.date.accessioned2016-04-28T16:09:07Zes_PE
dc.date.available2016-04-28T16:09:07Zes_PE
dc.date.issued2016-03es_PE
dc.identifier.issn1948-1756es_PE
dc.identifier.urihttp://hdl.handle.net/10757/607302es_PE
dc.description.abstractThe genetic architecture of placental abruption (PA) remains poorly understood. We examined variations in SNPs of circadian clock-related genes in placenta with PA risk. We also explored placental and maternal genomic contributions to PA risk. Placental genomic DNA samples were isolated from 280 PA cases and 244 controls. Genotyping was performed using the Illumina Cardio-MetaboChip. We examined 116 SNPs in 13 genes known to moderate circadian rhythms. Logistic regression models were fit to estimate odds ratios (ORs). The combined effect of multiple SNPs on PA risk was estimated using a weighted genetic risk score. We examined independent and joint associations of wGRS derived from placental and maternal genomes with PA. Seven SNPs in five genes (ARNTL2, CRY2, DEC1, PER3 and RORA), in the placental genome, were associated with PA risk. Each copy of the minor allele (G) of a SNP in the RORA gene (rs2899663) was associated with a 30% reduced odds of PA (95% CI 0.52-0.95). The odds of PA increased with increasing placental-wGRS (P<sub>trend</sub><0.001). The ORs were 1.00, 2.16, 3.24 and 4.48 across quartiles. Associations persisted after the maternal-wGRS was included in the model. There was evidence of an additive contribution of placental and maternal genetic contributions to PA risk. Participants with placental- and maternal-wGRS in the highest quartile, compared with those in the lowest quartile, had a 15.57-fold (95% CI 3.34- 72.60) increased odds of PA. Placental variants in circadian clock-related genes are associated with PA risk; and the association persists after control of genetic variants in the maternal genomees_PE
dc.formatapplication/pdfes_PE
dc.language.isoenges_PE
dc.publisherInternational Journal of Molecular Epidemiology and Geneticses_PE
dc.relation.urlhttp://www.ijmeg.org/IJMEG_V7N1.htmles_PE
dc.rightsinfo:eu-repo/semantics/openAccesses_PE
dc.sourceUniversidad Peruana de Ciencias Aplicadas (UPC)es_PE
dc.sourceRepositorio Académico - UPCes_PE
dc.subjectCircadian genees_PE
dc.subjectPlacental abruptiones_PE
dc.subjectPregnancyes_PE
dc.subjectPregnancyes_PE
dc.subjectPlacentaees_PE
dc.subjectSNPses_PE
dc.titlePlacental genetic variations in circadian clock-related genes increase the risk of placental abruptiones_PE
dc.typeinfo:eu-repo/semantics/articlees_PE
dc.identifier.journalInternational Journal of Molecular Epidemiology and Genetics (Int J Mol Epidemiol Genet)es_PE
dc.description.peer-reviewRevisión por pareses_PE
dc.contributor.emailChun-fang.Qiu@Swedish.orges_PE
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