Does vitamin D supplementation alter plasma adipokines concentrations? A systematic review and meta-analysis of randomized controlled trials.

2.50
Hdl Handle:
http://hdl.handle.net/10757/605887
Title:
Does vitamin D supplementation alter plasma adipokines concentrations? A systematic review and meta-analysis of randomized controlled trials.
Authors:
Dinca, Madalina; Serban, Maria-Corina; Sahebkar, Amirhossein; Mikhailidis, Dimitri P; Toth, Peter P; Martin, Seth S; Blaha, Michael J; Blüher, Matthias; Gurban, Camelia; Penson, Peter; Michos, Erin D; Hernandez, Adrian V. ( 0000-0002-9999-4003 ) ; Jones, Steven R; Banach, Maciej
Citation:
Does vitamin D supplementation alter plasma adipokines concentrations? A systematic review and meta-analysis of randomized controlled trials. 2016, 107:360-371 Pharmacol. Res.
Publisher:
Elsevier B.V.
Journal:
Pharmacological research
Issue Date:
30-Mar-2016
URI:
http://hdl.handle.net/10757/605887
DOI:
10.1016/j.phrs.2016.03.035
PubMed ID:
27038530
Additional Links:
https://www.researchgate.net/profile/Maciej_Banach/publication/298064313_Does_vitamin_D_supplementation_alter_plasma_adipokines_concentrations_A_systematic_review_and_meta-analysis_of_randomized_controlled_trials/links/56fefd7008aee995dde73c14.pdf
Abstract:
We aimed to elucidate the role of vitamin D supplementation on adipokines through a systematic review and a meta-analysis of randomized placebo-controlled trials (RCTs). The search included PUBMED, Scopus, Web of Science and Google Scholar through July 1st, 2015. Finally we identified 9 RCTs and 484 participants. Meta-analysis of data from 7 studies did not find a significant change in plasma adiponectin concentrations following vitamin D supplementation (mean difference [MD]: 4.45%, 95%CI: -3.04, 11.93, p=0.244; Q=2.18, I(2)=0%). In meta-regression, changes in plasma adiponectin concentrations following vitamin D supplementation were found to be independent of treatment duration (slope: 0.25; 95%CI: -0.69, 1.19; p=0.603) and changes in serum 25-hydroxy vitamin D [25(OH)D] levels (slope: -0.02; 95%CI: -0.15, 0.12; p=0.780). Meta-analysis of data from 6 studies did not find a significant change in plasma leptin concentrations following vitamin D supplementation (MD: -4.51%, 95%CI: -25.13, 16.11, p=0.668; Q=6.41, I(2)=21.97%). Sensitivity analysis showed that this effect size is sensitive to one of the studies; removing it resulted in a significant reduction in plasma leptin levels (MD: -12.81%, 95%CI: -24.33, -1.30, p=0.029). In meta-regression, changes in plasma leptin concentrations following vitamin D supplementation were found to be independent of treatment duration (slope: -1.93; 95%CI: -4.08, 0.23; p=0.080). However, changes in serum 25(OH)D were found to be significantly associated with changes in plasma leptin levels following vitamin D supplementation (slope: 1.05; 95%CI: 0.08, 2.02; p=0.033). In conclusion, current data did not indicate a significant effect of vitamin D supplementation on adiponectin and leptin levels.
Type:
info:eu-repo/semantics/article
Rights:
info:eu-repo/semantics/openAccess
Language:
eng
Keywords:
Vitamin D; Adiponectin; Leptin; Meta-analysis; Systematic review
ISSN:
1096-1186
Email:
maciejbanach@aol.co.uk

Full metadata record

DC FieldValue Language
dc.contributor.authorDinca, Madalinaes_PE
dc.contributor.authorSerban, Maria-Corinaes_PE
dc.contributor.authorSahebkar, Amirhosseines_PE
dc.contributor.authorMikhailidis, Dimitri Pes_PE
dc.contributor.authorToth, Peter Pes_PE
dc.contributor.authorMartin, Seth Ses_PE
dc.contributor.authorBlaha, Michael Jes_PE
dc.contributor.authorBlüher, Matthiases_PE
dc.contributor.authorGurban, Cameliaes_PE
dc.contributor.authorPenson, Peteres_PE
dc.contributor.authorMichos, Erin Des_PE
dc.contributor.authorHernandez, Adrian V.es_PE
dc.contributor.authorJones, Steven Res_PE
dc.contributor.authorBanach, Maciejes_PE
dc.date.accessioned2016-04-19T13:36:10Zes_PE
dc.date.available2016-04-19T13:36:10Zes_PE
dc.date.issued2016-03-30es_PE
dc.identifier.citationDoes vitamin D supplementation alter plasma adipokines concentrations? A systematic review and meta-analysis of randomized controlled trials. 2016, 107:360-371 Pharmacol. Res.es_PE
dc.identifier.issn1096-1186es_PE
dc.identifier.pmid27038530es_PE
dc.identifier.doi10.1016/j.phrs.2016.03.035es_PE
dc.identifier.urihttp://hdl.handle.net/10757/605887es_PE
dc.description.abstractWe aimed to elucidate the role of vitamin D supplementation on adipokines through a systematic review and a meta-analysis of randomized placebo-controlled trials (RCTs). The search included PUBMED, Scopus, Web of Science and Google Scholar through July 1st, 2015. Finally we identified 9 RCTs and 484 participants. Meta-analysis of data from 7 studies did not find a significant change in plasma adiponectin concentrations following vitamin D supplementation (mean difference [MD]: 4.45%, 95%CI: -3.04, 11.93, p=0.244; Q=2.18, I(2)=0%). In meta-regression, changes in plasma adiponectin concentrations following vitamin D supplementation were found to be independent of treatment duration (slope: 0.25; 95%CI: -0.69, 1.19; p=0.603) and changes in serum 25-hydroxy vitamin D [25(OH)D] levels (slope: -0.02; 95%CI: -0.15, 0.12; p=0.780). Meta-analysis of data from 6 studies did not find a significant change in plasma leptin concentrations following vitamin D supplementation (MD: -4.51%, 95%CI: -25.13, 16.11, p=0.668; Q=6.41, I(2)=21.97%). Sensitivity analysis showed that this effect size is sensitive to one of the studies; removing it resulted in a significant reduction in plasma leptin levels (MD: -12.81%, 95%CI: -24.33, -1.30, p=0.029). In meta-regression, changes in plasma leptin concentrations following vitamin D supplementation were found to be independent of treatment duration (slope: -1.93; 95%CI: -4.08, 0.23; p=0.080). However, changes in serum 25(OH)D were found to be significantly associated with changes in plasma leptin levels following vitamin D supplementation (slope: 1.05; 95%CI: 0.08, 2.02; p=0.033). In conclusion, current data did not indicate a significant effect of vitamin D supplementation on adiponectin and leptin levels.es_PE
dc.formatapplication/pdfes_PE
dc.language.isoenges_PE
dc.publisherElsevier B.V.es_PE
dc.relation.urlhttps://www.researchgate.net/profile/Maciej_Banach/publication/298064313_Does_vitamin_D_supplementation_alter_plasma_adipokines_concentrations_A_systematic_review_and_meta-analysis_of_randomized_controlled_trials/links/56fefd7008aee995dde73c14.pdfes_PE
dc.rightsinfo:eu-repo/semantics/openAccesses_PE
dc.sourceUniversidad Peruana de Ciencias Aplicadas (UPC)es_PE
dc.sourceRepositorio Académico - UPCes_PE
dc.subjectVitamin Des_PE
dc.subjectAdiponectines_PE
dc.subjectLeptines_PE
dc.subjectMeta-analysises_PE
dc.subjectSystematic reviewes_PE
dc.titleDoes vitamin D supplementation alter plasma adipokines concentrations? A systematic review and meta-analysis of randomized controlled trials.es_PE
dc.typeinfo:eu-repo/semantics/articlees_PE
dc.identifier.journalPharmacological researches_PE
dc.description.peer-reviewRevisión por pareses_PE
dc.contributor.emailmaciejbanach@aol.co.ukes_PE

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