Lineage II of Southeast Asian/American DENV-2 is Associated with a Severe Dengue Outbreak in the Peruvian Amazon

2.50
Hdl Handle:
http://hdl.handle.net/10757/605309
Title:
Lineage II of Southeast Asian/American DENV-2 is Associated with a Severe Dengue Outbreak in the Peruvian Amazon
Authors:
Williams, M.; Mayer, S. V.; Johnson, W. L.; Chen, R.; Volkova, E.; Vilcarromero, S.; Widen, S. G.; Wood, T. G.; Suarez Ognio, L.; Long, K. C.; Hanley, K. A.; Morrison, A. C.; Vasilakis, N.; Halsey, E. S.
Citation:
Lineage II of Southeast Asian/American DENV-2 is Associated with a Severe Dengue Outbreak in the Peruvian Amazon 2014, 91 (3):611 American Journal of Tropical Medicine and Hygiene
Publisher:
The American Society of Tropical Medicine and Hygiene
Journal:
American Journal of Tropical Medicine and Hygiene (Am. J. Trop. Med. Hyg)
Issue Date:
7-Jul-2014
URI:
http://hdl.handle.net/10757/605309
DOI:
10.4269/ajtmh.13-0600
Additional Links:
http://www.ajtmh.org/cgi/doi/10.4269/ajtmh.13-0600
Abstract:
During 2010 and 2011, the Loreto region of Peru experienced a dengue outbreak of unprecedented magnitude and severity for the region. This outbreak coincided with the reappearance of dengue virus-2 (DENV-2) in Loreto after almost 8 years. Whole-genome sequence indicated that DENV-2 from the outbreak belonged to lineage II of the southeast Asian/American genotype and was most closely related to viruses circulating in Brazil during 2007 and 2008, whereas DENV-2 previously circulating in Loreto grouped with lineage I (DENV-2 strains circulating in South America since 1990). One amino acid substitution (NS5 A811V) in the 2010 and 2011 isolates resulted from positive selection. However, the 2010 and 2011 DENV-2 did not replicate to higher titers in monocyte-derived dendritic cells and did not infect or disseminate in a higher proportion of Aedes aegypti than DENV-2 isolates previously circulating in Loreto. These results suggest that factors other than enhanced viral replication played a role in the severity of this outbreak.
Type:
info:eu-repo/semantics/article
Rights:
info:eu-repo/semantics/openAccess
Language:
eng
Keywords:
Dengue; Amazonas; Outbreak; DENV-2
ISSN:
0002-9637

Full metadata record

DC FieldValue Language
dc.contributor.authorWilliams, M.es_PE
dc.contributor.authorMayer, S. V.es_PE
dc.contributor.authorJohnson, W. L.es_PE
dc.contributor.authorChen, R.es_PE
dc.contributor.authorVolkova, E.es_PE
dc.contributor.authorVilcarromero, S.es_PE
dc.contributor.authorWiden, S. G.es_PE
dc.contributor.authorWood, T. G.es_PE
dc.contributor.authorSuarez Ognio, L.es_PE
dc.contributor.authorLong, K. C.es_PE
dc.contributor.authorHanley, K. A.es_PE
dc.contributor.authorMorrison, A. C.es_PE
dc.contributor.authorVasilakis, N.es_PE
dc.contributor.authorHalsey, E. S.es_PE
dc.date.accessioned2016-04-14T16:16:57Zes_PE
dc.date.available2016-04-14T16:16:57Zes_PE
dc.date.issued2014-07-07es_PE
dc.identifier.citationLineage II of Southeast Asian/American DENV-2 is Associated with a Severe Dengue Outbreak in the Peruvian Amazon 2014, 91 (3):611 American Journal of Tropical Medicine and Hygienees_PE
dc.identifier.issn0002-9637es_PE
dc.identifier.doi10.4269/ajtmh.13-0600es_PE
dc.identifier.urihttp://hdl.handle.net/10757/605309es_PE
dc.description.abstractDuring 2010 and 2011, the Loreto region of Peru experienced a dengue outbreak of unprecedented magnitude and severity for the region. This outbreak coincided with the reappearance of dengue virus-2 (DENV-2) in Loreto after almost 8 years. Whole-genome sequence indicated that DENV-2 from the outbreak belonged to lineage II of the southeast Asian/American genotype and was most closely related to viruses circulating in Brazil during 2007 and 2008, whereas DENV-2 previously circulating in Loreto grouped with lineage I (DENV-2 strains circulating in South America since 1990). One amino acid substitution (NS5 A811V) in the 2010 and 2011 isolates resulted from positive selection. However, the 2010 and 2011 DENV-2 did not replicate to higher titers in monocyte-derived dendritic cells and did not infect or disseminate in a higher proportion of Aedes aegypti than DENV-2 isolates previously circulating in Loreto. These results suggest that factors other than enhanced viral replication played a role in the severity of this outbreak.es_PE
dc.formatapplication/pdfes_PE
dc.language.isoenges_PE
dc.publisherThe American Society of Tropical Medicine and Hygienees_PE
dc.relation.urlhttp://www.ajtmh.org/cgi/doi/10.4269/ajtmh.13-0600es_PE
dc.rightsinfo:eu-repo/semantics/openAccesses_PE
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourceUniversidad Peruana de Ciencias Aplicadas (UPC)es_PE
dc.sourceRepositorio Académico - UPCes_PE
dc.subjectDenguees_PE
dc.subjectAmazonases_PE
dc.subjectOutbreakes_PE
dc.subjectDENV-2es_PE
dc.titleLineage II of Southeast Asian/American DENV-2 is Associated with a Severe Dengue Outbreak in the Peruvian Amazones_PE
dc.typeinfo:eu-repo/semantics/articlees_PE
dc.identifier.journalAmerican Journal of Tropical Medicine and Hygiene (Am. J. Trop. Med. Hyg)es_PE
This item is licensed under a Creative Commons License
Creative Commons
All Items in UPC are protected by copyright, with all rights reserved, unless otherwise indicated.