Utility of presepsin (sCD14-ST) as a diagnostic and prognostic marker of sepsis in the emergency department

2.50
Hdl Handle:
http://hdl.handle.net/10757/576944
Title:
Utility of presepsin (sCD14-ST) as a diagnostic and prognostic marker of sepsis in the emergency department
Authors:
Carpio, Ricardo; Zapata, Juan; Spanuth, Eberhard; Hess, Georg
Citation:
Carpio Ricardo, Zapata Juan, Spanuth Eberhard, Hess Georg, Utility of presepsin (sCD14-ST) as a diagnostic and prognostic marker of sepsis in the emergency department, Clinica Chimica Acta (2015), doi: 10.1016/j.cca.2015.08.013
Publisher:
Elsevier B.V.
Journal:
Clinica Chimica Acta (Clin Chim Acta)
Issue Date:
8-Sep-2015
URI:
http://hdl.handle.net/10757/576944
DOI:
10.1016/j.cca.2015.08.013
Additional Links:
http://www.sciencedirect.com/science/journal/00098981
Abstract:
Presepsin (PSEP) is released during infectious diseases and can be detected in the blood. PSEP has shown promising results as sepsis marker. We examined the diagnostic and prognostic validity of PSEP in patients suspicious of sepsis on admission in the emergency department (ED). Methods One hundred twenty three patients with signs of SIRS and/or sepsis and 123 healthy individuals were enrolled. PSEP was determined on admission, after 8, 24 and 72 h. Results Mean PSEP concentrations of the control group and the patient group were 130 and 1945 pg/ml. PSEP differed between SIRS, sepsis, severe sepsis and septic shock and showed strong association with 30-day mortality ranging from 10.3% in the 1st to 32.1% in the 4th quartile. The ROC curve analyses revealed an AUC value of 0.743. Combined assessment of PSEP and MEDS score increased the AUC up to 0.878 demonstrating the close relationship with outcome. Based on the PSEP values in the different severity degrees, decision thresholds for risk stratification were established. The course of PSEP during the first 72 h was associated with effectiveness of treatment and outcome. Conclusions PSEP allowed outcome prediction already on admission to a similar degree as the clinical scores MEDS and APACHE II. Combination of PSEP with MEDS score improved the discriminatory power for outcome prediction.
Type:
info:eu-repo/semantics/article
Rights:
info:eu-repo/semantics/openAccess
Language:
eng
Keywords:
Presepsin; Emergency department; Sepsis; Diagnosis; Prognosis; Outcome prediction
ISSN:
0009-8981
EISSN:
1873-3492

Full metadata record

DC FieldValue Language
dc.contributor.authorCarpio, Ricardoes_PE
dc.contributor.authorZapata, Juanes_PE
dc.contributor.authorSpanuth, Eberhardes_PE
dc.contributor.authorHess, Georges_PE
dc.date.accessioned2015-09-08T15:07:27Zes_PE
dc.date.available2015-09-08T15:07:27Zes_PE
dc.date.issued2015-09-08es_PE
dc.identifier.citationCarpio Ricardo, Zapata Juan, Spanuth Eberhard, Hess Georg, Utility of presepsin (sCD14-ST) as a diagnostic and prognostic marker of sepsis in the emergency department, Clinica Chimica Acta (2015), doi: 10.1016/j.cca.2015.08.013es_PE
dc.identifier.issn0009-8981es_PE
dc.identifier.doi10.1016/j.cca.2015.08.013es_PE
dc.identifier.urihttp://hdl.handle.net/10757/576944es_PE
dc.description.abstractPresepsin (PSEP) is released during infectious diseases and can be detected in the blood. PSEP has shown promising results as sepsis marker. We examined the diagnostic and prognostic validity of PSEP in patients suspicious of sepsis on admission in the emergency department (ED). Methods One hundred twenty three patients with signs of SIRS and/or sepsis and 123 healthy individuals were enrolled. PSEP was determined on admission, after 8, 24 and 72 h. Results Mean PSEP concentrations of the control group and the patient group were 130 and 1945 pg/ml. PSEP differed between SIRS, sepsis, severe sepsis and septic shock and showed strong association with 30-day mortality ranging from 10.3% in the 1st to 32.1% in the 4th quartile. The ROC curve analyses revealed an AUC value of 0.743. Combined assessment of PSEP and MEDS score increased the AUC up to 0.878 demonstrating the close relationship with outcome. Based on the PSEP values in the different severity degrees, decision thresholds for risk stratification were established. The course of PSEP during the first 72 h was associated with effectiveness of treatment and outcome. Conclusions PSEP allowed outcome prediction already on admission to a similar degree as the clinical scores MEDS and APACHE II. Combination of PSEP with MEDS score improved the discriminatory power for outcome prediction.eng
dc.formatapplication/pdfes_PE
dc.language.isoenges_PE
dc.publisherElsevier B.V.es_PE
dc.relation.urlhttp://www.sciencedirect.com/science/journal/00098981es_PE
dc.rightsinfo:eu-repo/semantics/openAccesses_PE
dc.sourceUniversidad Peruana de Ciencias Aplicadas (UPC)es_PE
dc.sourceRepositorio Académico - UPCes_PE
dc.subjectPresepsines_PE
dc.subjectEmergency departmentes_PE
dc.subjectSepsises_PE
dc.subjectDiagnosises_PE
dc.subjectPrognosises_PE
dc.subjectOutcome predictiones_PE
dc.titleUtility of presepsin (sCD14-ST) as a diagnostic and prognostic marker of sepsis in the emergency departmentes_PE
dc.typeinfo:eu-repo/semantics/articlees_PE
dc.identifier.eissn1873-3492es_PE
dc.identifier.journalClinica Chimica Acta (Clin Chim Acta)es_PE
dc.description.fundingOur study has been supported by Mitsubishi Chemical Europe through providing the PSEP reagents free of charge. Dr. Carpio has received speaker honoraria from Mitsubishi Chemical Europe. DIAneering – Diagnostics Engineering & Research consulted to Axis Shield Diagnostics, Mitsubishi Chemical Europe, Radiometer, Roche Diagnostics, Shanghai Kehua Bio-engineering. No potential conflict of interest to this paper was reportedes_PE
dc.description.peer-reviewPeer reviewes_PE
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