Outbreak of Cutaneous Leishmaniasis in Peruvian Military Personnel Undertaking Training Activities in the Amazon Basin, 2010

2.50
Hdl Handle:
http://hdl.handle.net/10757/558294
Title:
Outbreak of Cutaneous Leishmaniasis in Peruvian Military Personnel Undertaking Training Activities in the Amazon Basin, 2010
Authors:
Oré,Marianela; Sáenz, Eliana; Cabrera, Rufino; Sanchez, Juan F.; De Los Santos, Maxy; Lucas, Carmen M.; Núñez, Jorge; Edgel, Kimberly A.; Sopan, Justino; Fernández, Jorge; Carnero, G, Andres M.; Baldeviano, Christian; Arrasco, Juan C.; Graf, Paul C. F.; Lescano, Andres G.
Publisher:
American Society of Tropical Medicine and Hygiene
Journal:
American Journal of Tropical Medicine and Hygiene (ajtmh)
Issue Date:
20-Jun-2015
URI:
http://hdl.handle.net/10757/558294
DOI:
10.4269/ajtmh.15-0107
Additional Links:
http://www.ajtmh.org/content/early/2015/06/11/ajtmh.15-0107.full.pdf+html
Abstract:
Military personnel deployed to the Amazon Basin are at high risk for cutaneous leishmaniasis (CL). We responded to an outbreak among Peruvian Army personnel returning from short-term training in the Amazon, conducting active case detection, lesion sample collection, and risk factor assessment. The attack rate was 25% (76/303); the incubation period was 2–36 weeks (median = 8). Most cases had one lesion (66%), primarily ulcerative (49%), and in the legs (57%). Real-time polymerase chain reaction (PCR) identified Leishmania (Viannia) braziliensis (59/61 = 97%) and L. (V.) guyanensis (2/61 = 3%). Being male (risk ratio [RR] = 4.01; P = 0.034), not wearing long-sleeve clothes (RR = 1.71; P = 0.005), and sleeping in open rooms (RR = 1.80; P = 0.009) were associated with CL. Sodium stibogluconate therapy had a 41% cure rate, less than previously reported in Peru (70%; P < 0.001). After emphasizing pre-deployment education and other basic prevention measures, trainees in the following year had lower incidence (1/278 = 0.4%; P < 0.001). Basic prevention can reduce CL risk in deployed militaries.
Type:
info:eu-repo/semantics/article
Rights:
info:eu-repo/semantics/openAccess
Language:
eng
Description:
Article
Keywords:
Leishmaniasis; Peruvian Military Personnel; Training Activities; Peru
ISSN:
0002-9637
EISSN:
1476-1645

Full metadata record

DC FieldValue Language
dc.contributor.authorOré,Marianelaes_PE
dc.contributor.authorSáenz, Elianaes_PE
dc.contributor.authorCabrera, Rufinoes_PE
dc.contributor.authorSanchez, Juan F.es_PE
dc.contributor.authorDe Los Santos, Maxyes_PE
dc.contributor.authorLucas, Carmen M.es_PE
dc.contributor.authorNúñez, Jorgees_PE
dc.contributor.authorEdgel, Kimberly A.es_PE
dc.contributor.authorSopan, Justinoes_PE
dc.contributor.authorFernández, Jorgees_PE
dc.contributor.authorCarnero, G, Andres M.es_PE
dc.contributor.authorBaldeviano, Christianes_PE
dc.contributor.authorArrasco, Juan C.es_PE
dc.contributor.authorGraf, Paul C. F.es_PE
dc.contributor.authorLescano, Andres G.es_PE
dc.date.accessioned2015-06-20T14:33:03Zes_PE
dc.date.available2015-06-20T14:33:03Zes_PE
dc.date.issued2015-06-20es_PE
dc.identifier.issn0002-9637es_PE
dc.identifier.doi10.4269/ajtmh.15-0107es_PE
dc.identifier.urihttp://hdl.handle.net/10757/558294es_PE
dc.descriptionArticlees_PE
dc.description.abstractMilitary personnel deployed to the Amazon Basin are at high risk for cutaneous leishmaniasis (CL). We responded to an outbreak among Peruvian Army personnel returning from short-term training in the Amazon, conducting active case detection, lesion sample collection, and risk factor assessment. The attack rate was 25% (76/303); the incubation period was 2–36 weeks (median = 8). Most cases had one lesion (66%), primarily ulcerative (49%), and in the legs (57%). Real-time polymerase chain reaction (PCR) identified Leishmania (Viannia) braziliensis (59/61 = 97%) and L. (V.) guyanensis (2/61 = 3%). Being male (risk ratio [RR] = 4.01; P = 0.034), not wearing long-sleeve clothes (RR = 1.71; P = 0.005), and sleeping in open rooms (RR = 1.80; P = 0.009) were associated with CL. Sodium stibogluconate therapy had a 41% cure rate, less than previously reported in Peru (70%; P < 0.001). After emphasizing pre-deployment education and other basic prevention measures, trainees in the following year had lower incidence (1/278 = 0.4%; P < 0.001). Basic prevention can reduce CL risk in deployed militaries.eng
dc.formatapplication/pdfes_PE
dc.language.isoenges_PE
dc.publisherAmerican Society of Tropical Medicine and Hygienees_PE
dc.relation.urlhttp://www.ajtmh.org/content/early/2015/06/11/ajtmh.15-0107.full.pdf+htmles_PE
dc.rightsinfo:eu-repo/semantics/openAccesses_PE
dc.sourceUniversidad Peruana de Ciencias Aplicadas (UPC)es_PE
dc.sourceRepositorio Académico - UPCes_PE
dc.subjectLeishmaniasises_PE
dc.subjectPeruvian Military Personneles_PE
dc.subjectTraining Activitieses_PE
dc.subjectPerues_PE
dc.titleOutbreak of Cutaneous Leishmaniasis in Peruvian Military Personnel Undertaking Training Activities in the Amazon Basin, 2010es_PE
dc.typeinfo:eu-repo/semantics/articlees_PE
dc.identifier.eissn1476-1645es_PE
dc.identifier.journalAmerican Journal of Tropical Medicine and Hygiene (ajtmh)es_PE
dc.description.fundingThe outbreak response was supported by the Peruvian Army Health Command COSALE and the Peruvian Ministry of Health through the General Epidemiology Directorate and the Health Directorate II, south Lima, and the. In addition, partial support was provided by grants CO497_11_L1 and CO466_11_L1 of the Global Emerging Infections Surveillance and Response System (AFHSC/GEIS) of the U.S. Department of Defense and the training grant 2D43 TW007393 awarded to the U.S. Naval Medical Research Unit No. 6 (NAMRU-6) by the Fogarty International Center of the National Institutes of Health (FIC/NIH). This study is part of the dissertation of Marianela Ore for a Masters in Epidemiological Research offered jointly by the Universidad Peruana Cayetano Heredia (UPCH) and NAMRU-6.es_PE
dc.durationmaryore05@yahoo.eses_PE
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