Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials
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Authors
Perez López, Faustino R.Pasupuleti, Vinay
Mezones-Holguín, Edward
Thota, Priyaleela
Deshpande, Abhishek
Hernández, Adrian V.
Benítes-Zapata, Vicente A.
Issue Date
2015-03-30
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Pasupuleti V, Mezones-holguin E, Benites-zapata VA, Thota P, Deshpande A, Hernandez A V. Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes : a systematic review and meta-analysis of randomized controlled trials. Fertil Steril [Internet]. 2015;(Feb). Available from: http://hdl.handle.net/10757/347325Publisher
Elsevier B.V.Journal
Fertility and SterilityDOI
10.1016/j.fertnstert.2015.02.019Additional Links
http://www.fertstert.org/article/S0015-0282%2815%2900149-1/abstractAbstract
Objective: To assess the effects of vitamin D supplementation during pregnancy on obstetric outcomes and birth variables. Design: Systematic review and meta-analysis of randomized controlled trials (RCTs). Setting: Not applicable. Patient(s): Pregnant women and neonates. Intervention(s): PubMed and 5 other research databases were searched through March 2014 for RCTs evaluating vitamin D supplementation calcium/vitamins/ferrous sulfate vs. a control (placebo or active) during pregnancy. Main Outcome Measure(s): Measures were: circulating 25-hydroxyvitamin D [25(OH)D] levels, preeclampsia, gestational diabetes mellitus (GDM), small for gestational age (SGA), low birth weight, preterm birth, birth weight, birth length, cesarean section. Mantel-Haenszel fixed-effects models were used, owing to expected scarcity of outcomes. Effects were reported as relative risks and their 95% confidence intervals (CIs). Result(s): Thirteen RCTs (n ¼ 2,299) were selected. Circulating 25(OH)D levels were significantly higher at term, compared with the control group (mean difference: 66.5 nmol/L, 95% CI 66.2–66.7). Birth weight and birth length were significantly greater for neonates in the vitamin D group; mean difference: 107.6 g (95% CI 59.9–155.3 g) and 0.3 cm (95% CI 0.10–0.41 cm), respectively. Incidence of preeclampsia, GDM, SGA, low birth weight, preterm birth, and cesarean section were not influenced by vitamin D supplementation. Across RCTs, the doses and types of vitamin D supplements, gestational age at first administration, and outcomes were heterogeneous. Conclusion(s): Vitamin D supplementation during pregnancy was associated with increased circulating 25(OH)D levels, birth weight, and birth length, and was not associated with other maternal and neonatal outcomes. Larger, better-designed RCTs evaluating clinically relevant outcomes are necessary to reach a definitive conclusion. (Fertil Steril 2015;-:-–-. 2015 by American Society for Reproductive Medicine.)Type
info:eu-repo/semantics/articleRights
info:eu-repo/semantics/openAccessLanguage
engDescription
[email protected]ISSN
0015-0282EISSN
1556-5653ae974a485f413a2113503eed53cd6c53
10.1016/j.fertnstert.2015.02.019
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