Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials

2.50
Hdl Handle:
http://hdl.handle.net/10757/347325
Title:
Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials
Authors:
Perez López, Faustino R.; Pasupuleti, Vinay; Mezones Holguín, Edward ( 0000-0001-7168-8613 ) ; Benites Zapata, Vicente A.; Thota, Priyaleela; Deshpande, Abhishek; Hernández, Adrian V. ( 0000-0002-9999-4003 )
Citation:
Pasupuleti V, Mezones-holguin E, Benites-zapata VA, Thota P, Deshpande A, Hernandez A V. Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes : a systematic review and meta-analysis of randomized controlled trials. Fertil Steril [Internet]. 2015;(Feb). Available from: http://hdl.handle.net/10757/347325
Publisher:
Elsevier B.V.
Journal:
Fertility and Sterility
Issue Date:
30-Mar-2015
URI:
http://hdl.handle.net/10757/347325
DOI:
10.1016/j.fertnstert.2015.02.019
Additional Links:
http://www.fertstert.org/article/S0015-0282%2815%2900149-1/abstract
Abstract:
Objective: To assess the effects of vitamin D supplementation during pregnancy on obstetric outcomes and birth variables. Design: Systematic review and meta-analysis of randomized controlled trials (RCTs). Setting: Not applicable. Patient(s): Pregnant women and neonates. Intervention(s): PubMed and 5 other research databases were searched through March 2014 for RCTs evaluating vitamin D supplementation calcium/vitamins/ferrous sulfate vs. a control (placebo or active) during pregnancy. Main Outcome Measure(s): Measures were: circulating 25-hydroxyvitamin D [25(OH)D] levels, preeclampsia, gestational diabetes mellitus (GDM), small for gestational age (SGA), low birth weight, preterm birth, birth weight, birth length, cesarean section. Mantel-Haenszel fixed-effects models were used, owing to expected scarcity of outcomes. Effects were reported as relative risks and their 95% confidence intervals (CIs). Result(s): Thirteen RCTs (n ¼ 2,299) were selected. Circulating 25(OH)D levels were significantly higher at term, compared with the control group (mean difference: 66.5 nmol/L, 95% CI 66.2–66.7). Birth weight and birth length were significantly greater for neonates in the vitamin D group; mean difference: 107.6 g (95% CI 59.9–155.3 g) and 0.3 cm (95% CI 0.10–0.41 cm), respectively. Incidence of preeclampsia, GDM, SGA, low birth weight, preterm birth, and cesarean section were not influenced by vitamin D supplementation. Across RCTs, the doses and types of vitamin D supplements, gestational age at first administration, and outcomes were heterogeneous. Conclusion(s): Vitamin D supplementation during pregnancy was associated with increased circulating 25(OH)D levels, birth weight, and birth length, and was not associated with other maternal and neonatal outcomes. Larger, better-designed RCTs evaluating clinically relevant outcomes are necessary to reach a definitive conclusion. (Fertil Steril 2015;-:-–-. 2015 by American Society for Reproductive Medicine.)
Type:
info:eu-repo/semantics/article
Rights:
info:eu-repo/semantics/openAccess
Language:
eng
Description:
faustino.perez@unizar.es
Keywords:
Vitamin D; Pregnancy; Maternal outcomes; Neonatal outcomes; Meta-analysis
ISSN:
0015-0282
EISSN:
1556-5653

Full metadata record

DC FieldValue Language
dc.contributor.authorPerez López, Faustino R.es_PE
dc.contributor.authorPasupuleti, Vinayes_PE
dc.contributor.authorMezones Holguín, Edwardes_PE
dc.contributor.authorBenites Zapata, Vicente A.es_PE
dc.contributor.authorThota, Priyaleelaes_PE
dc.contributor.authorDeshpande, Abhishekes_PE
dc.contributor.authorHernández, Adrian V.es_PE
dc.date.accessioned2015-03-30T19:31:08Zes_PE
dc.date.available2015-03-30T19:31:08Zes_PE
dc.date.issued2015-03-30es_PE
dc.identifier.citationPasupuleti V, Mezones-holguin E, Benites-zapata VA, Thota P, Deshpande A, Hernandez A V. Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes : a systematic review and meta-analysis of randomized controlled trials. Fertil Steril [Internet]. 2015;(Feb). Available from: http://hdl.handle.net/10757/347325es_PE
dc.identifier.issn0015-0282es_PE
dc.identifier.doi10.1016/j.fertnstert.2015.02.019es_PE
dc.identifier.urihttp://hdl.handle.net/10757/347325es_PE
dc.descriptionfaustino.perez@unizar.eses_PE
dc.description.abstractObjective: To assess the effects of vitamin D supplementation during pregnancy on obstetric outcomes and birth variables. Design: Systematic review and meta-analysis of randomized controlled trials (RCTs). Setting: Not applicable. Patient(s): Pregnant women and neonates. Intervention(s): PubMed and 5 other research databases were searched through March 2014 for RCTs evaluating vitamin D supplementation calcium/vitamins/ferrous sulfate vs. a control (placebo or active) during pregnancy. Main Outcome Measure(s): Measures were: circulating 25-hydroxyvitamin D [25(OH)D] levels, preeclampsia, gestational diabetes mellitus (GDM), small for gestational age (SGA), low birth weight, preterm birth, birth weight, birth length, cesarean section. Mantel-Haenszel fixed-effects models were used, owing to expected scarcity of outcomes. Effects were reported as relative risks and their 95% confidence intervals (CIs). Result(s): Thirteen RCTs (n ¼ 2,299) were selected. Circulating 25(OH)D levels were significantly higher at term, compared with the control group (mean difference: 66.5 nmol/L, 95% CI 66.2–66.7). Birth weight and birth length were significantly greater for neonates in the vitamin D group; mean difference: 107.6 g (95% CI 59.9–155.3 g) and 0.3 cm (95% CI 0.10–0.41 cm), respectively. Incidence of preeclampsia, GDM, SGA, low birth weight, preterm birth, and cesarean section were not influenced by vitamin D supplementation. Across RCTs, the doses and types of vitamin D supplements, gestational age at first administration, and outcomes were heterogeneous. Conclusion(s): Vitamin D supplementation during pregnancy was associated with increased circulating 25(OH)D levels, birth weight, and birth length, and was not associated with other maternal and neonatal outcomes. Larger, better-designed RCTs evaluating clinically relevant outcomes are necessary to reach a definitive conclusion. (Fertil Steril 2015;-:-–-. 2015 by American Society for Reproductive Medicine.)eng
dc.formatapplication/pdfes_PE
dc.language.isoenges_PE
dc.publisherElsevier B.V.es_PE
dc.relation.urlhttp://www.fertstert.org/article/S0015-0282%2815%2900149-1/abstractes_PE
dc.rightsinfo:eu-repo/semantics/openAccesses_PE
dc.sourceUniversidad Peruana de Ciencias Aplicadas (UPC)es_PE
dc.sourceRepositorio Académico - UPCes_PE
dc.subjectVitamin Des_PE
dc.subjectPregnancyes_PE
dc.subjectMaternal outcomeses_PE
dc.subjectNeonatal outcomeses_PE
dc.subjectMeta-analysises_PE
dc.titleEffect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trialses_PE
dc.typeinfo:eu-repo/semantics/articlees_PE
dc.identifier.eissn1556-5653es_PE
dc.identifier.journalFertility and Sterilityes_PE
dc.description.peer-reviewRevisión por pareses_PE
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