Diarrheagenic Escherichia coli Phylogroups Are Associated with Antibiotic Resistance and Duration of Diarrheal Episode

2.50
Hdl Handle:
http://hdl.handle.net/10757/345715
Title:
Diarrheagenic Escherichia coli Phylogroups Are Associated with Antibiotic Resistance and Duration of Diarrheal Episode
Authors:
Mosquito, Susan; Pons, Maria J.; Riveros, Maribel; Ruiz, Joaquim; Ochoa, Theresa J.
Citation:
Susan Mosquito, Maria J. Pons, Maribel Riveros, Joaquim Ruiz, and Theresa J. Ochoa, “Diarrheagenic Escherichia coli Phylogroups Are Associated with Antibiotic Resistance and Duration of Diarrheal Episode,” The Scientific World Journal, vol. 2015, Article ID 610403, 6 pages, 2015. doi:10.1155/2015/610403
Publisher:
Hindawi Publishing Corporation
Journal:
The Scientific World Journal
Issue Date:
27-Feb-2015
URI:
http://hdl.handle.net/10757/345715
DOI:
10.1155/2015/610403
Additional Links:
http://www.hindawi.com/journals/tswj/2015/610403/cta/
Abstract:
Conventionally, in Escherichia coli, phylogenetic groups A and B1 are associated with commensal strains while B2 and D are associated with extraintestinal strains. The aim of this study was to evaluate diarrheagenic (DEC) and commensal E. coli phylogeny and its association with antibiotic resistance and clinical characteristics of the diarrheal episode. Phylogenetic groups and antibiotic resistance of 369 E. coli strains (commensal strains and DEC from children with or without diarrhea) isolated from Peruvian children <1 year of age were determined by a Clermont triplex PCR and Kirby-Bauer method, respectively. The distribution of the 369 E. coli strains among the 4 phylogenetic groups was A (40%), D (31%), B1 (21%), and B2 (8%). DEC-control strains were more associated with group A while DEC-diarrhea strains were more associated with group D (𝑃 < 0.05). There was a tendency (𝑃 = 0.06) for higher proportion of persistent diarrhea (≥14 days) among severe groups (B2 and D) in comparison with nonsevere groups (A and B1). Strains belonging to group D presented significantly higher percentages of multidrug resistance than the rest of the groups (𝑃 > 0.01). In summary, DEC-diarrhea strains were more associated with group D than strains from healthy controls.
Type:
info:eu-repo/semantics/article
Rights:
info:eu-repo/semantics/openAccess
Language:
eng
Keywords:
Escherichia Coli; Antibiotic Resistance
ISSN:
2356-6140
EISSN:
1537-744X

Full metadata record

DC FieldValue Language
dc.contributor.authorMosquito, Susanes_PE
dc.contributor.authorPons, Maria J.es_PE
dc.contributor.authorRiveros, Maribeles_PE
dc.contributor.authorRuiz, Joaquimes_PE
dc.contributor.authorOchoa, Theresa J.es_PE
dc.date.accessioned2015-02-27T16:22:48Zes_PE
dc.date.available2015-02-27T16:22:48Zes_PE
dc.date.issued2015-02-27es_PE
dc.identifier.citationSusan Mosquito, Maria J. Pons, Maribel Riveros, Joaquim Ruiz, and Theresa J. Ochoa, “Diarrheagenic Escherichia coli Phylogroups Are Associated with Antibiotic Resistance and Duration of Diarrheal Episode,” The Scientific World Journal, vol. 2015, Article ID 610403, 6 pages, 2015. doi:10.1155/2015/610403es_PE
dc.identifier.issn2356-6140es_PE
dc.identifier.doi10.1155/2015/610403es_PE
dc.identifier.urihttp://hdl.handle.net/10757/345715es_PE
dc.description.abstractConventionally, in Escherichia coli, phylogenetic groups A and B1 are associated with commensal strains while B2 and D are associated with extraintestinal strains. The aim of this study was to evaluate diarrheagenic (DEC) and commensal E. coli phylogeny and its association with antibiotic resistance and clinical characteristics of the diarrheal episode. Phylogenetic groups and antibiotic resistance of 369 E. coli strains (commensal strains and DEC from children with or without diarrhea) isolated from Peruvian children <1 year of age were determined by a Clermont triplex PCR and Kirby-Bauer method, respectively. The distribution of the 369 E. coli strains among the 4 phylogenetic groups was A (40%), D (31%), B1 (21%), and B2 (8%). DEC-control strains were more associated with group A while DEC-diarrhea strains were more associated with group D (𝑃 < 0.05). There was a tendency (𝑃 = 0.06) for higher proportion of persistent diarrhea (≥14 days) among severe groups (B2 and D) in comparison with nonsevere groups (A and B1). Strains belonging to group D presented significantly higher percentages of multidrug resistance than the rest of the groups (𝑃 > 0.01). In summary, DEC-diarrhea strains were more associated with group D than strains from healthy controls.eng
dc.formatapplication/pdfes_PE
dc.language.isoenges_PE
dc.publisherHindawi Publishing Corporationes_PE
dc.relation.urlhttp://www.hindawi.com/journals/tswj/2015/610403/cta/es_PE
dc.rightsinfo:eu-repo/semantics/openAccesses_PE
dc.sourceUniversidad Peruana de Ciencias Aplicadas (UPC)es_PE
dc.sourceRepositorio Académico - UPCes_PE
dc.subjectEscherichia Colies_PE
dc.subjectAntibiotic Resistancees_PE
dc.titleDiarrheagenic Escherichia coli Phylogroups Are Associated with Antibiotic Resistance and Duration of Diarrheal Episodees_PE
dc.typeinfo:eu-repo/semantics/articlees_PE
dc.identifier.eissn1537-744Xes_PE
dc.identifier.journalThe Scientific World Journales_PE
dc.description.fundingThis study was partially supported by the Agencia Española de Cooperación Internacional (AECID), Spain, Programa de Cooperación Interuniversitaria e Investigación Científica con Iberoamérica (D/019499/08, D/024648/09, and D/030509/10) (TJ and JR). Theresa J. Ochoa is supported by the National Institute of Health, USA, Public Health Service award RO1-HDO67694-01A1. Joaquim Ruiz is supported by I3 program, of the Ministerio de Economia y Competitividad, Spain (Grant no. CES11/012). Maria J. Pons has a postdoctoral fellowship from CONCYTEC/FONDECYT.eng
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