Usefulness of Neutrophil-to-Lymphocyte Ratio in Risk Stratification of Patients With Advanced Heart Failure

5.00
Hdl Handle:
http://hdl.handle.net/10757/338009
Title:
Usefulness of Neutrophil-to-Lymphocyte Ratio in Risk Stratification of Patients With Advanced Heart Failure
Authors:
Benites Zapata, Vicente A.; Hernández, Adrian V. ( 0000-0002-9999-4003 ) ; Nagarajan, Vijaiganesh; Cauthen, Clay A.; Starling, Randall C.; Tang, W.H. Wilson
Citation:
1. Benites-Zapata VA, Hernandez AV, Nagarajan V, Cauthen CA, Starling RC, Wilson Tang WH. Usefulness of Neutrophil-to-Lymphocyte Ratio in Risk Stratification of Patients With Advanced Heart Failure. The American Journal of Cardiology. 1 de enero de 2015;115(1):57-61.
Publisher:
Elsevier B.V.
Journal:
The American Journal of Cardiology (Am J Cardiol.)
Issue Date:
9-Jan-2015
URI:
http://hdl.handle.net/10757/338009
DOI:
10.1016/j.amjcard.2014.10.008
Additional Links:
http://www.sciencedirect.com/science/article/pii/S0002914914019298; http://www.ajconline.org/article/S0002-9149%2814%2901929-8/abstract
Abstract:
Elevated neutrophil-to-lymphocyte ratio (NLR) has been associated with increased mortality in patients with acute heart failure (HF) and neoplastic diseases. We investigated the association between NLR and mortality or cardiac transplantation in a retrospective cohort of 527 patients presented to the Cleveland Clinic for evaluation of advanced HF therapy options from 2007 to 2010. Patients were divided according to low, intermediate, and high tertiles of NLR and were followed longitudinally for time to all-cause mortality or heart transplantation (primary outcome). The median NLR was 3.9 (interquartile range 2.5 to 6.5). In univariate analysis, intermediate and highest tertiles of NLR had a higher risk than the lowest tertile for the primary outcome and all-causes mortality. Compared with the lowest tertile, there was no difference in the risk of heart transplantation for intermediate and high tertiles. In multivariate analysis, compared with the lowest tertile, the intermediate and high NLR tertiles remained significantly associated with the primary outcome (hazard ratio [HR] [ 1.61, 95% confidence interval [CI] 1.10 to 2.37 and HR [ 1.55, 95% CI 1.02 to 2.36, respectively) and all-cause mortality (HR [ 1.83, 95% CI 1.07 to 3.14 and HR [ 2.16, 95% CI 1.21 to 3.83, respectively). In conclusion, elevated NLR is associated with increased mortality or heart transplantation risk in patients with advanced HF.
Type:
info:eu-repo/semantics/article
Rights:
info:eu-repo/semantics/openAccess
Language:
eng
ISSN:
0002-9149

Full metadata record

DC FieldValue Language
dc.contributor.authorBenites Zapata, Vicente A.es_PE
dc.contributor.authorHernández, Adrian V.es_PE
dc.contributor.authorNagarajan, Vijaiganeshes_PE
dc.contributor.authorCauthen, Clay A.es_PE
dc.contributor.authorStarling, Randall C.es_PE
dc.contributor.authorTang, W.H. Wilsones_PE
dc.date.accessioned2015-01-09T16:38:09Z-
dc.date.available2015-01-09T16:38:09Z-
dc.date.issued2015-01-09-
dc.identifier.citation1. Benites-Zapata VA, Hernandez AV, Nagarajan V, Cauthen CA, Starling RC, Wilson Tang WH. Usefulness of Neutrophil-to-Lymphocyte Ratio in Risk Stratification of Patients With Advanced Heart Failure. The American Journal of Cardiology. 1 de enero de 2015;115(1):57-61.es_PE
dc.identifier.issn0002-9149-
dc.identifier.doi10.1016/j.amjcard.2014.10.008-
dc.identifier.urihttp://hdl.handle.net/10757/338009es_PE
dc.description.abstractElevated neutrophil-to-lymphocyte ratio (NLR) has been associated with increased mortality in patients with acute heart failure (HF) and neoplastic diseases. We investigated the association between NLR and mortality or cardiac transplantation in a retrospective cohort of 527 patients presented to the Cleveland Clinic for evaluation of advanced HF therapy options from 2007 to 2010. Patients were divided according to low, intermediate, and high tertiles of NLR and were followed longitudinally for time to all-cause mortality or heart transplantation (primary outcome). The median NLR was 3.9 (interquartile range 2.5 to 6.5). In univariate analysis, intermediate and highest tertiles of NLR had a higher risk than the lowest tertile for the primary outcome and all-causes mortality. Compared with the lowest tertile, there was no difference in the risk of heart transplantation for intermediate and high tertiles. In multivariate analysis, compared with the lowest tertile, the intermediate and high NLR tertiles remained significantly associated with the primary outcome (hazard ratio [HR] [ 1.61, 95% confidence interval [CI] 1.10 to 2.37 and HR [ 1.55, 95% CI 1.02 to 2.36, respectively) and all-cause mortality (HR [ 1.83, 95% CI 1.07 to 3.14 and HR [ 2.16, 95% CI 1.21 to 3.83, respectively). In conclusion, elevated NLR is associated with increased mortality or heart transplantation risk in patients with advanced HF.eng
dc.formatapplication/pdfes_PE
dc.language.isoenges_PE
dc.publisherElsevier B.V.es_PE
dc.relation.urlhttp://www.sciencedirect.com/science/article/pii/S0002914914019298es_PE
dc.relation.urlhttp://www.ajconline.org/article/S0002-9149%2814%2901929-8/abstractes_PE
dc.rightsinfo:eu-repo/semantics/openAccesses_PE
dc.sourceUniversidad Peruana de Ciencias Aplicadas (UPC)es_PE
dc.sourceRepositorio Académico - UPCes_PE
dc.titleUsefulness of Neutrophil-to-Lymphocyte Ratio in Risk Stratification of Patients With Advanced Heart Failurees_PE
dc.typeinfo:eu-repo/semantics/articlees_PE
dc.identifier.journalThe American Journal of Cardiology (Am J Cardiol.)es_PE
dc.description.peer-reviewRevisión por pareses_PE
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