Antiviral activity of maca (Lepidium meyenii) against human influenza virus

2.50
Hdl Handle:
http://hdl.handle.net/10757/335865
Title:
Antiviral activity of maca (Lepidium meyenii) against human influenza virus
Authors:
Del Valle Mendoza, Juana; Pumarola, Tomàs; Alzamora Gonzales, Libertad; Del Valle, Luis J.
Citation:
Del Valle Mendoza J, Pumarola T, Gonzales LA, del Valle LJ. Antiviral activity of maca (Lepidium meyenii) against human influenza virus. Asian Pacific Journal of Tropical Medicine. septiembre de 2014;7, Supplement 1:S415-20.
Publisher:
Elsevier B.V.
Journal:
Asian Pacific Journal of Tropical Medicine
Issue Date:
20-Nov-2014
URI:
http://hdl.handle.net/10757/335865
DOI:
10.1016/S1995-7645(14)60268-6
Additional Links:
http://www.sciencedirect.com/science/article/pii/S1995764514602686
Abstract:
Objective: To investigate antiviral activity of maca to reduce viral load in kidney (MDCK) cells infected with influenza type A and B viruses (Flu-A and MFalud-inB-, Dreasrpbeyc ctiavneilny)e. Methods: Maca were extracted with methanol (1:2, v/v). The cell viability and toxicity of the eaxgtariancstts Fwluer-eA e avnaldu aFtleud- oBn v MirDusCeKs cwealsls a usssianyge dm uetshinogd aM TteTs ta sfosar yd. eAtenrtmiviinrainl ga ctthiev itiyn hoifb citoimonp oouf nthdes cytopathic effect on cell culture and multiplex RT-PCR. Results: The methanol extract of maca showed low cytotoxicity and inhibited influenza-induced cytopathic effect significantly, while viral load was reduced via inhibition of viral growth in MDCK infected cells. Maca contains potent inhibitors of Flu-A and Flu-B with a selectivity index [cytotoxic concentration 50%/IC50] of 157.4 and 110.5, respectively. Conclusions: In vitro assays demonstrated that maca has antiviral activity not only against Flu-A (like most antiviral agents) but also Flu-B viruses, providing remarkable therapeutic benefits.
Type:
info:eu-repo/semantics/article
Rights:
info:eu-repo/semantics/openAccess
Language:
eng
Keywords:
Influenza virus flu; Antiviral activity; Lepidium meyenii; Maca
ISSN:
1995-7645
Sponsors:
Financial support of this study was provided by AECID grants (PCI: C/033641/10) and AGAUR (MAT2009-11503, MAT2012-36205, 2009SGR-1208). JDVM support was provided by 1st Concurso Incentivo a la Investigación de la Universidad Peruana de Ciencias Aplicadas, Lima, Peru.
Email:
jdevall@upc.edu.pe

Full metadata record

DC FieldValue Language
dc.contributor.authorDel Valle Mendoza, Juanaspa
dc.contributor.authorPumarola, Tomàsspa
dc.contributor.authorAlzamora Gonzales, Libertadspa
dc.contributor.authorDel Valle, Luis J.spa
dc.date.accessioned2014-11-21T00:58:58Zes
dc.date.available2014-11-21T00:58:58Zes
dc.date.issued2014-11-20es
dc.identifier.citationDel Valle Mendoza J, Pumarola T, Gonzales LA, del Valle LJ. Antiviral activity of maca (Lepidium meyenii) against human influenza virus. Asian Pacific Journal of Tropical Medicine. septiembre de 2014;7, Supplement 1:S415-20.spa
dc.identifier.issn1995-7645es
dc.identifier.doi10.1016/S1995-7645(14)60268-6spa
dc.identifier.urihttp://hdl.handle.net/10757/335865es
dc.description.abstractObjective: To investigate antiviral activity of maca to reduce viral load in kidney (MDCK) cells infected with influenza type A and B viruses (Flu-A and MFalud-inB-, Dreasrpbeyc ctiavneilny)e. Methods: Maca were extracted with methanol (1:2, v/v). The cell viability and toxicity of the eaxgtariancstts Fwluer-eA e avnaldu aFtleud- oBn v MirDusCeKs cwealsls a usssianyge dm uetshinogd aM TteTs ta sfosar yd. eAtenrtmiviinrainl ga ctthiev itiyn hoifb citoimonp oouf nthdes cytopathic effect on cell culture and multiplex RT-PCR. Results: The methanol extract of maca showed low cytotoxicity and inhibited influenza-induced cytopathic effect significantly, while viral load was reduced via inhibition of viral growth in MDCK infected cells. Maca contains potent inhibitors of Flu-A and Flu-B with a selectivity index [cytotoxic concentration 50%/IC50] of 157.4 and 110.5, respectively. Conclusions: In vitro assays demonstrated that maca has antiviral activity not only against Flu-A (like most antiviral agents) but also Flu-B viruses, providing remarkable therapeutic benefits.spa
dc.description.sponsorshipFinancial support of this study was provided by AECID grants (PCI: C/033641/10) and AGAUR (MAT2009-11503, MAT2012-36205, 2009SGR-1208). JDVM support was provided by 1st Concurso Incentivo a la Investigación de la Universidad Peruana de Ciencias Aplicadas, Lima, Peru.spa
dc.formatapplication/pdfspa
dc.language.isoengeng
dc.publisherElsevier B.V.spa
dc.relation.urlhttp://www.sciencedirect.com/science/article/pii/S1995764514602686spa
dc.rightsinfo:eu-repo/semantics/openAccessspa
dc.subjectInfluenza virus fluspa
dc.subjectAntiviral activityspa
dc.subjectLepidium meyeniispa
dc.subjectMacaspa
dc.titleAntiviral activity of maca (Lepidium meyenii) against human influenza virusspa
dc.typeinfo:eu-repo/semantics/articlespa
dc.identifier.journalAsian Pacific Journal of Tropical Medicinespa
dc.description.peer-reviewRevisión por paresspa
dc.contributor.emailjdevall@upc.edu.pespa
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