Weight variation over time and its relevance among multidrug-resistant tuberculosis patients

2.50
Hdl Handle:
http://hdl.handle.net/10757/326115
Title:
Weight variation over time and its relevance among multidrug-resistant tuberculosis patients
Authors:
Chung Delgado, Kocfa; Revilla Montag, Alejandro; Guillén Bravo, Sonia; Bernabe Ortiz, Antonio
Publisher:
Elsevier B.V.
Journal:
International Journal of Infectious Diseases
Issue Date:
15-Sep-2014
URI:
http://hdl.handle.net/10757/326115
DOI:
10.1016/j.ijid.2014.01.001
Additional Links:
http://www.sciencedirect.com/science/article/pii/S120197121400037X
Abstract:
Objectives: We aimed to assess the variation in patient body weight over time according to the treatment outcome among multidrug-resistant tuberculosis (MDR-TB) cases. Methods: This was a retrospective cohort study. The data of patients commencing MDR-TB therapy were analyzed. Data were collected from different public TB treatment facilities located in peri-urban areas to the south of Lima, Peru. The outcome was patient body weight (kilograms) from treatment commencement, measured monthly. A random effects model was fitted using robust standard errors to calculate 95% confidence intervals. Results: Of a total of 1242 TB cases, 243 (19.6%) were MDR-TB. Only 201 cases were included in the analysis; 127 (63.2%) were males and the mean patient age was 33.6 (standard deviation 16.2) years. Weight changes over time among the patients who were cured differed from changes in those who died during therapy (p < 0.001). Weight curve divergence was important at the end of the third, fourth, and fifth treatment months: on average, the weight difference was 2.18 kg (p < 0.001), 3.27 kg (p = 0.007), and 3.58 kg (p = 0.03), respectively, when cured patients were compared to those who died. Conclusions: Our results show that weight variation during treatment can be a useful surrogate for the treatment outcome, specifically death during therapy. MDR-TB patients with weight loss should be followed more closely, as they are at greater risk of death.
Type:
info:eu-repo/semantics/article
Rights:
info:eu-repo/semantics/openAccess
Language:
eng
Keywords:
Tuberculosis; Multidrug-resistant tuberculosis; Treatment outcome; Weight
ISSN:
1201-9712
EISSN:
1878-3511

Full metadata record

DC FieldValue Language
dc.contributor.authorChung Delgado, Kocfaspa
dc.contributor.authorRevilla Montag, Alejandrospa
dc.contributor.authorGuillén Bravo, Soniaspa
dc.contributor.authorBernabe Ortiz, Antoniospa
dc.date.accessioned2014-09-16T03:07:58Z-
dc.date.available2014-09-16T03:07:58Z-
dc.date.issued2014-09-15-
dc.identifier.issn1201-9712-
dc.identifier.doi10.1016/j.ijid.2014.01.001-
dc.identifier.urihttp://hdl.handle.net/10757/326115-
dc.description.abstractObjectives: We aimed to assess the variation in patient body weight over time according to the treatment outcome among multidrug-resistant tuberculosis (MDR-TB) cases. Methods: This was a retrospective cohort study. The data of patients commencing MDR-TB therapy were analyzed. Data were collected from different public TB treatment facilities located in peri-urban areas to the south of Lima, Peru. The outcome was patient body weight (kilograms) from treatment commencement, measured monthly. A random effects model was fitted using robust standard errors to calculate 95% confidence intervals. Results: Of a total of 1242 TB cases, 243 (19.6%) were MDR-TB. Only 201 cases were included in the analysis; 127 (63.2%) were males and the mean patient age was 33.6 (standard deviation 16.2) years. Weight changes over time among the patients who were cured differed from changes in those who died during therapy (p < 0.001). Weight curve divergence was important at the end of the third, fourth, and fifth treatment months: on average, the weight difference was 2.18 kg (p < 0.001), 3.27 kg (p = 0.007), and 3.58 kg (p = 0.03), respectively, when cured patients were compared to those who died. Conclusions: Our results show that weight variation during treatment can be a useful surrogate for the treatment outcome, specifically death during therapy. MDR-TB patients with weight loss should be followed more closely, as they are at greater risk of death.eng
dc.formatapplication/pdfspa
dc.language.isoengeng
dc.publisherElsevier B.V.spa
dc.relation.urlhttp://www.sciencedirect.com/science/article/pii/S120197121400037Xspa
dc.rightsinfo:eu-repo/semantics/openAccessspa
dc.subjectTuberculosisspa
dc.subjectMultidrug-resistant tuberculosiseng
dc.subjectTreatment outcomespa
dc.subjectWeightspa
dc.titleWeight variation over time and its relevance among multidrug-resistant tuberculosis patientsspa
dc.typeinfo:eu-repo/semantics/articlespa
dc.identifier.eissn1878-3511-
dc.identifier.journalInternational Journal of Infectious Diseasesspa
dc.description.peer-reviewRevisión por paresspa
This item is licensed under a Creative Commons License
Creative Commons
All Items in UPC are protected by copyright, with all rights reserved, unless otherwise indicated.