Refractory Thrombocytopenia Responds to Octreotide Treatment in a Case of Evans Syndrome with Gastric Neuroendocrine Tumor

2.50
Hdl Handle:
http://hdl.handle.net/10757/314004
Title:
Refractory Thrombocytopenia Responds to Octreotide Treatment in a Case of Evans Syndrome with Gastric Neuroendocrine Tumor
Authors:
Chung Delgado, Kocfa; Revilla Montag, Alejandro; Guillén Bravo, Sonia; Ríos Díaz, Hugo; Alva Muñoz, José C.
Citation:
Case Reports in Hematology Volume 2013, Article ID 391086, 5 pages
Publisher:
Hindawi Publishing Corporation
Issue Date:
12-Mar-2014
URI:
http://hdl.handle.net/10757/314004
DOI:
http://dx.doi.org/10.1155/2013/391086
Additional Links:
http://www.hindawi.com/journals/crihem/2013/391086/
Abstract:
A 37-year-old woman with history of Evans Syndrome with poor response to high-dose corticoid treatment presented to the emergency department with gastrointestinal and vaginal bleeding. The patient was later diagnosed with severe thrombocytopenia and a stage G1, well-differentiated gastric neuroendocrine tumor, confirmed by a biopsy. A total gastrectomy was performed to eradicate the tumor. After being treated with a total splenectomy for her Evans Syndrome with no clinical or laboratory improvement, she began regular treatment with octreotide on the basis of a possible hepatic metastasis. Days after the initiation of the octreotide, an increase in the platelet count was evidenced by laboratory findings, from 2,000 platelets/mm3 to 109,000 platelets/mm3 . Weeks later, the hepatic metastasis is discarded by a negative octreotide-body scan, and the octreotide treatment was interrupted. Immediately after the drug interruption, a progressive and evident descent in the platelet count was evidenced (4000 platelets/mm3 ). The present case report highlights the possible association between octreotide treatment and a severe thrombocytopenia resistant to conventional treatment.
Type:
info:eu-repo/semantics/article
Rights:
info:eu-repo/semantics/openAccess
Language:
eng
ISSN:
2090-6560
EISSN:
2090-6579

Full metadata record

DC FieldValue Language
dc.contributor.authorChung Delgado, Kocfaes_PE
dc.contributor.authorRevilla Montag, Alejandroes_PE
dc.contributor.authorGuillén Bravo, Soniaes_PE
dc.contributor.authorRíos Díaz, Hugoes_PE
dc.contributor.authorAlva Muñoz, José C.es_PE
dc.date.accessioned2014-03-13T02:16:10Z-
dc.date.available2014-03-13T02:16:10Z-
dc.date.issued2014-03-12-
dc.identifier.citationCase Reports in Hematology Volume 2013, Article ID 391086, 5 pageses_PE
dc.identifier.issn2090-6560-
dc.identifier.doihttp://dx.doi.org/10.1155/2013/391086-
dc.identifier.urihttp://hdl.handle.net/10757/314004es_PE
dc.description.abstractA 37-year-old woman with history of Evans Syndrome with poor response to high-dose corticoid treatment presented to the emergency department with gastrointestinal and vaginal bleeding. The patient was later diagnosed with severe thrombocytopenia and a stage G1, well-differentiated gastric neuroendocrine tumor, confirmed by a biopsy. A total gastrectomy was performed to eradicate the tumor. After being treated with a total splenectomy for her Evans Syndrome with no clinical or laboratory improvement, she began regular treatment with octreotide on the basis of a possible hepatic metastasis. Days after the initiation of the octreotide, an increase in the platelet count was evidenced by laboratory findings, from 2,000 platelets/mm3 to 109,000 platelets/mm3 . Weeks later, the hepatic metastasis is discarded by a negative octreotide-body scan, and the octreotide treatment was interrupted. Immediately after the drug interruption, a progressive and evident descent in the platelet count was evidenced (4000 platelets/mm3 ). The present case report highlights the possible association between octreotide treatment and a severe thrombocytopenia resistant to conventional treatment.eng
dc.formatapplication/pdfes_PE
dc.language.isoenges_PE
dc.publisherHindawi Publishing Corporationes_PE
dc.relation.urlhttp://www.hindawi.com/journals/crihem/2013/391086/es_PE
dc.rightsinfo:eu-repo/semantics/openAccesses_PE
dc.sourceUniversidad Peruana de Ciencias Aplicadas (UPC)es_PE
dc.sourceRepositorio Académico - UPCes_PE
dc.titleRefractory Thrombocytopenia Responds to Octreotide Treatment in a Case of Evans Syndrome with Gastric Neuroendocrine Tumores_PE
dc.typeinfo:eu-repo/semantics/articlees_PE
dc.identifier.eissn2090-6579-
dc.identifier.orcid0000-0003-1962-9434eng
dc.description.peer-reviewRevisión por pareses_PE
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