Factors Associated with Anti-Tuberculosis Medication Adverse Effects: A Case-Control Study in Lima, Peru

2.50
Hdl Handle:
http://hdl.handle.net/10757/313811
Title:
Factors Associated with Anti-Tuberculosis Medication Adverse Effects: A Case-Control Study in Lima, Peru
Authors:
Chung Delgado, Kocfa; Revilla Montag, Alejandro; Guillen Bravo, Sonia; Velez Segovia, Eduardo; Soria Montoya, Andrea; Nuñez Garbin, Alexandra; Silva Caso, Wilmer; Bernabe Ortiz, Antonio
Citation:
PLoS ONE 6(11): e27610
Publisher:
Public Library of Science (PLoS)
Issue Date:
7-Mar-2014
URI:
http://hdl.handle.net/10757/313811
DOI:
10.1371/journal.pone.0027610
Additional Links:
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0027610
Abstract:
Background: Long-term exposure to anti-tuberculosis medication increases risk of adverse drug reactions and toxicity. The objective of this investigation was to determine factors associated with anti-tuberculosis adverse drug reactions in Lima, Peru, with special emphasis on MDR-TB medication, HIV infection, diabetes, age and tobacco use. Methodology and Results: A case-control study was performed using information from Peruvian TB Programme. A case was defined as having reported an anti-TB adverse drug reaction during 2005–2010 with appropriate notification on clinical records. Controls were defined as not having reported a side effect, receiving anti-TB therapy during the same time that the case had appeared. Crude, and age- and sex-adjusted models were calculated using odds ratios (OR) and 95% confidence intervals (95%CI). A multivariable model was created to look for independent factors associated with side effect from anti-TB therapy. A total of 720 patients (144 cases and 576 controls) were analyzed. In our multivariable model, age, especially those over 40 years (OR = 3.93; 95%CI: 1.65–9.35), overweight/obesity (OR = 2.13; 95%CI: 1.17–3.89), anemia (OR = 2.10; IC95%: 1.13–3.92), MDR-TB medication (OR = 11.1; 95%CI: 6.29–19.6), and smoking (OR = 2.00; 95%CI: 1.03–3.87) were independently associated with adverse drug reactions. Conclusions: Old age, anemia, MDR-TB medication, overweight/obesity status, and smoking history are independent risk factors associated with anti-tuberculosis adverse drug reactions. Patients with these risk factors should be monitored during the anti-TB therapy. A comprehensive clinical history and additional medical exams, including hematocrit and HIV-ELISA, might be useful to identify these patients.
Type:
info:eu-repo/semantics/article
Rights:
info:eu-repo/semantics/openAccess
Language:
eng
EISSN:
1932-6203

Full metadata record

DC FieldValue Language
dc.contributor.authorChung Delgado, Kocfaspa
dc.contributor.authorRevilla Montag, Alejandrospa
dc.contributor.authorGuillen Bravo, Soniaspa
dc.contributor.authorVelez Segovia, Eduardospa
dc.contributor.authorSoria Montoya, Andreaspa
dc.contributor.authorNuñez Garbin, Alexandraspa
dc.contributor.authorSilva Caso, Wilmerspa
dc.contributor.authorBernabe Ortiz, Antoniospa
dc.date.accessioned2014-03-07T21:32:02Z-
dc.date.available2014-03-07T21:32:02Z-
dc.date.issued2014-03-07-
dc.identifier.citationPLoS ONE 6(11): e27610spa
dc.identifier.doi10.1371/journal.pone.0027610-
dc.identifier.urihttp://hdl.handle.net/10757/313811-
dc.description.abstractBackground: Long-term exposure to anti-tuberculosis medication increases risk of adverse drug reactions and toxicity. The objective of this investigation was to determine factors associated with anti-tuberculosis adverse drug reactions in Lima, Peru, with special emphasis on MDR-TB medication, HIV infection, diabetes, age and tobacco use. Methodology and Results: A case-control study was performed using information from Peruvian TB Programme. A case was defined as having reported an anti-TB adverse drug reaction during 2005–2010 with appropriate notification on clinical records. Controls were defined as not having reported a side effect, receiving anti-TB therapy during the same time that the case had appeared. Crude, and age- and sex-adjusted models were calculated using odds ratios (OR) and 95% confidence intervals (95%CI). A multivariable model was created to look for independent factors associated with side effect from anti-TB therapy. A total of 720 patients (144 cases and 576 controls) were analyzed. In our multivariable model, age, especially those over 40 years (OR = 3.93; 95%CI: 1.65–9.35), overweight/obesity (OR = 2.13; 95%CI: 1.17–3.89), anemia (OR = 2.10; IC95%: 1.13–3.92), MDR-TB medication (OR = 11.1; 95%CI: 6.29–19.6), and smoking (OR = 2.00; 95%CI: 1.03–3.87) were independently associated with adverse drug reactions. Conclusions: Old age, anemia, MDR-TB medication, overweight/obesity status, and smoking history are independent risk factors associated with anti-tuberculosis adverse drug reactions. Patients with these risk factors should be monitored during the anti-TB therapy. A comprehensive clinical history and additional medical exams, including hematocrit and HIV-ELISA, might be useful to identify these patients.eng
dc.formatapplication/pdfspa
dc.language.isoengeng
dc.publisherPublic Library of Science (PLoS)spa
dc.relation.urlhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0027610spa
dc.rightsinfo:eu-repo/semantics/openAccessspa
dc.titleFactors Associated with Anti-Tuberculosis Medication Adverse Effects: A Case-Control Study in Lima, Peruspa
dc.typeinfo:eu-repo/semantics/articlespa
dc.identifier.eissn1932-6203-
dc.identifier.orcid0000-0003-1962-9434eng
dc.description.peer-reviewRevisión por pareseng
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