Factors Associated with Anti-Tuberculosis Medication Adverse Effects: A Case-Control Study in Lima, Peru

2.50
Hdl Handle:
http://hdl.handle.net/10757/313811
Title:
Factors Associated with Anti-Tuberculosis Medication Adverse Effects: A Case-Control Study in Lima, Peru
Authors:
Chung Delgado, Kocfa; Revilla Montag, Alejandro; Guillen Bravo, Sonia; Velez Segovia, Eduardo; Soria Montoya, Andrea; Nuñez Garbin, Alexandra; Silva Caso, Wilmer; Bernabe Ortiz, Antonio
Citation:
PLoS ONE 6(11): e27610
Publisher:
Public Library of Science (PLoS)
Issue Date:
7-Mar-2014
URI:
http://hdl.handle.net/10757/313811
DOI:
10.1371/journal.pone.0027610
Additional Links:
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0027610
Abstract:
Background: Long-term exposure to anti-tuberculosis medication increases risk of adverse drug reactions and toxicity. The objective of this investigation was to determine factors associated with anti-tuberculosis adverse drug reactions in Lima, Peru, with special emphasis on MDR-TB medication, HIV infection, diabetes, age and tobacco use. Methodology and Results: A case-control study was performed using information from Peruvian TB Programme. A case was defined as having reported an anti-TB adverse drug reaction during 2005–2010 with appropriate notification on clinical records. Controls were defined as not having reported a side effect, receiving anti-TB therapy during the same time that the case had appeared. Crude, and age- and sex-adjusted models were calculated using odds ratios (OR) and 95% confidence intervals (95%CI). A multivariable model was created to look for independent factors associated with side effect from anti-TB therapy. A total of 720 patients (144 cases and 576 controls) were analyzed. In our multivariable model, age, especially those over 40 years (OR = 3.93; 95%CI: 1.65–9.35), overweight/obesity (OR = 2.13; 95%CI: 1.17–3.89), anemia (OR = 2.10; IC95%: 1.13–3.92), MDR-TB medication (OR = 11.1; 95%CI: 6.29–19.6), and smoking (OR = 2.00; 95%CI: 1.03–3.87) were independently associated with adverse drug reactions. Conclusions: Old age, anemia, MDR-TB medication, overweight/obesity status, and smoking history are independent risk factors associated with anti-tuberculosis adverse drug reactions. Patients with these risk factors should be monitored during the anti-TB therapy. A comprehensive clinical history and additional medical exams, including hematocrit and HIV-ELISA, might be useful to identify these patients.
Type:
info:eu-repo/semantics/article
Rights:
info:eu-repo/semantics/openAccess
Language:
eng
EISSN:
1932-6203

Full metadata record

DC FieldValue Language
dc.contributor.authorChung Delgado, Kocfaes_PE
dc.contributor.authorRevilla Montag, Alejandroes_PE
dc.contributor.authorGuillen Bravo, Soniaes_PE
dc.contributor.authorVelez Segovia, Eduardoes_PE
dc.contributor.authorSoria Montoya, Andreaes_PE
dc.contributor.authorNuñez Garbin, Alexandraes_PE
dc.contributor.authorSilva Caso, Wilmeres_PE
dc.contributor.authorBernabe Ortiz, Antonioes_PE
dc.date.accessioned2014-03-07T21:32:02Z-
dc.date.available2014-03-07T21:32:02Z-
dc.date.issued2014-03-07-
dc.identifier.citationPLoS ONE 6(11): e27610es_PE
dc.identifier.doi10.1371/journal.pone.0027610-
dc.identifier.urihttp://hdl.handle.net/10757/313811es_PE
dc.description.abstractBackground: Long-term exposure to anti-tuberculosis medication increases risk of adverse drug reactions and toxicity. The objective of this investigation was to determine factors associated with anti-tuberculosis adverse drug reactions in Lima, Peru, with special emphasis on MDR-TB medication, HIV infection, diabetes, age and tobacco use. Methodology and Results: A case-control study was performed using information from Peruvian TB Programme. A case was defined as having reported an anti-TB adverse drug reaction during 2005–2010 with appropriate notification on clinical records. Controls were defined as not having reported a side effect, receiving anti-TB therapy during the same time that the case had appeared. Crude, and age- and sex-adjusted models were calculated using odds ratios (OR) and 95% confidence intervals (95%CI). A multivariable model was created to look for independent factors associated with side effect from anti-TB therapy. A total of 720 patients (144 cases and 576 controls) were analyzed. In our multivariable model, age, especially those over 40 years (OR = 3.93; 95%CI: 1.65–9.35), overweight/obesity (OR = 2.13; 95%CI: 1.17–3.89), anemia (OR = 2.10; IC95%: 1.13–3.92), MDR-TB medication (OR = 11.1; 95%CI: 6.29–19.6), and smoking (OR = 2.00; 95%CI: 1.03–3.87) were independently associated with adverse drug reactions. Conclusions: Old age, anemia, MDR-TB medication, overweight/obesity status, and smoking history are independent risk factors associated with anti-tuberculosis adverse drug reactions. Patients with these risk factors should be monitored during the anti-TB therapy. A comprehensive clinical history and additional medical exams, including hematocrit and HIV-ELISA, might be useful to identify these patients.eng
dc.formatapplication/pdfes_PE
dc.language.isoenges_PE
dc.publisherPublic Library of Science (PLoS)es_PE
dc.relation.urlhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0027610es_PE
dc.rightsinfo:eu-repo/semantics/openAccesses_PE
dc.sourceUniversidad Peruana de Ciencias Aplicadas (UPC)es_PE
dc.sourceRepositorio Académico - UPCes_PE
dc.titleFactors Associated with Anti-Tuberculosis Medication Adverse Effects: A Case-Control Study in Lima, Perues_PE
dc.typeinfo:eu-repo/semantics/articlees_PE
dc.identifier.eissn1932-6203-
dc.identifier.orcid0000-0003-1962-9434eng
dc.description.peer-reviewRevisión por pareseng
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